This study confirmed the anti-inflammatory effect through the intracellular inflammatory response mechanism in HaCaT cells stimulated with TNF-α/IFN-γ and the HMC-1 cells model stimulated with PMACI, which is mainly used in allergic contact dermatitis research, as well as DNCB-induced ACD-like skin lesions. Here, TNF is linked to granular corneal dystrophy type II.