Thus, this study demonstrated the effects of CP in TNF-α/IFN-γ-stimulated HaCaT cells, PMACI (phorbol-12-myristate-13-acetate plus A23187)-stimulated HMC-1 cells, and DNCB-induced ACD-like skin lesions in a Balb/c mouse model. The gene discussed is IFNG; the disease is granular corneal dystrophy type II.