Regarding the influence of the BM microenvironment on the BCL-2 family of proteins, IL6-mediated signals have been shown to promote MCL-1 overexpression and dependence in MM [27,35], with phosphorylation of BIM shifting its binding from BCL-2 and BCL-XL to MCL-1 [17]. This evidence concerns the gene BCL2L11 and Miyoshi myopathy.