ERBB2 and type 1 diabetes mellitus: In addition, the analyses consistently predicted upregulation of the receptor tyrosine-protein kinase ERBB2 gene product (ERBB2), which is involved in the activation of inflammatory responses mediated by pro-inflammatory metabolites, such as glutamic acid, glycine, and cholesterol (Figure 4A) [73,74,75], and has been strongly implicated in T1D [76,77,78].