In this same study, increased nitration and ubiquitin-conjugation of β-catenin (AJ), plakoglobin (adherens junction/desmosomes), claudin-1 (TJ), and claudin-4 (TJ) was observed in the intestines of binge alcohol-exposed mice, which, once again, correlated with endotoxemia and, thus, gut leakiness and fatty liver disease [121]. The gene discussed is CLDN1; the disease is serum lipopolysaccharide activity.