Pomegranate extract, in particular, reduced ethanol-induced global nitration and ubiquitination of intestinal proteins and, specifically, ethanol-induced claudin-1 nitration and ubiquitination, thus preventing its degradation, and all of these PTM changes correlated with the prevention of intestinal barrier damage, and endotoxemia [120]. This evidence concerns the gene CLDN1 and serum lipopolysaccharide activity.