CYP2E1 and fatty liver disease: Importantly, the observed increase in plasma endotoxin levels, oxidative stress (determined via increased 3-nitrotyrosine (3-NT) levels), and intestinal permeability was dependent on intestinal CYP2E1, since Cyp2e1-null mice were quite resistant to binge alcohol-mediated gut leakiness and subsequent fatty liver [120,132,159].