As demonstrated in Figure 8B, intrarenal ACE2 activity was significantly higher in the medulla in PCOS rats (78.468 ± 9.311 vs. 48.707 ± 4.515 pmol/min.mg protein, p < 0.05) compared to the PCOS cortex, and unchanged in controls. This evidence concerns the gene ACE2 and polycystic ovary syndrome.