ACE and polycystic ovary syndrome: EMPA treatment in PCOS rats decreased ACE mRNA expression compared to untreated PCOS rats in the renal medulla (2.38 ± 0.13 vs. 4.07 ± 0.11, p < 0.0001), and in the renal cortex (0.96 ± 0.07 vs. 1.44 ± 0.19, p = 0.194).