ACE and polycystic ovary syndrome: As shown in Figure 8A, intrarenal ACE activity was significantly higher in the medulla in both PCOS rats (9.965 ± 0.890 vs. 1.625 ± 0.345 nmol/min.mg protein, p < 0.0001) and controls (9.441 ± 0.856 vs. 1.115 ± 0.287 nmol/min.mg protein, p < 0.0001) compared to the renal cortex.