EMPA decreased medullar ACE protein in both PCOS rats (0.954 ± 0.015 vs. 0.991 ± 0.005, p < 0.05) and controls (0.933 ± 0.009 vs. 1.000 ± 0.006, p < 0.01). Here, ACE is linked to polycystic ovary syndrome.