HIF1A and neoplasm: Taking into consideration that it is HIF-1 that mediates the expression of HK2, GLUT1 and PDK1 and formation of the “Warburg phenotype” within hypoxic tumors [114,115], the inhibitory targeting of HIF-1α may abolish both the hypoxia-associated energy metabolism reprogramming in tumor cells and their high radioresistance conferred by this reprogramming (see the previous subsections and Table 1).