WEE1 and neoplasm: Being the main player in triggering HSP expression, HSF1 also regulates the HIF-1α expression and tumor-driving HIF-1-HuR pathway, some protein kinase-based signaling pathways, autophagy, the energy metabolism and the redox potential, as well as the expression of certain microRNAs and long noncoding RNAs [160,161,162,163]; such activities allow HSF1 to contribute to many traits of tumor cells, including their ability to adapt to hypoxia and survive radiation exposure.