It was revealed in cells of hepatocarcinoma (Huh7 line) and cervical carcinoma (HeLa line) that, under hypoxia, mortalin (GRP75) mediates both the translocation of non-phosphorylated HIF-1α to the outer mitochondrial membrane and its association with VDAC1 and HK2, which leads to the modulation of VDAC1 activity and, as a result, the protection of the hypoxia-stressed cancer cells from apoptosis [40]. This evidence concerns the gene HK2 and cancer.