SOX9 and hepatocellular carcinoma: In human hepatoma cells, the knockdown of hypoxia-responsive circRNA ZNF292 resulted in an increased SRY (sex-determining region Y)-box 9 (SOX9) nuclear translocation, followed by inhibition of the Wnt/β-catenin pathway; eventually, this led to suppression of both the proliferation and enhancement of radioresistance in hypoxic hepatoma cells in vitro and in vivo [327].