In a model with laryngeal squamous carcinoma CNE-2 stem cells, the NF-κB/HIF-1 signaling pathway was shown to maintain a cancer stemness and high radioresistance in CD133-positive CSCs, whereas the inhibition of this HIF-1-involving pathway reversed the EMT and diminished the radioresistance [26]. Here, NFKB1 is linked to cancer.