In this respect, encouraging data were reported by Zhou et al. [91], who succeeded in the radiosensitization of hypoxic tumor cells in a murine model of breast cancer using yolk-shell Cu2-xSe@PtSe nanoparticles (a nanosensitizer) with acriflavine (an HIF-1α inhibitor) on their surface. Here, HIF1A is linked to breast carcinoma.