In particular, histone demethylase JMJD2B was shown to promote the resistance of hypoxic gastric cancer cells to γ-irradiation; the radioprotective function of JMJD2B was suggested to be due to the JMJD2B-mediated upregulation of cyclin A1 (CCNA1), while JMJD2B was suggested to be a therapeutic target to overcome the hypoxia-induced radioresistance of tumors [332]. This evidence concerns the gene KDM4B and gastric cancer.