EIF2AK3 and cancer: In an in vitro breast cancer model, lysosome-associated membrane protein 3 (LAMP3) induced by the PERK/ATF4 arm of the UPR during hypoxia was shown to be required for DNA double-stranded break repair in cancer MDA-MB-231 cells and their radioresistance [240]; both LAMP3 knockdown and the chemical inhibition of PERK with GSK2606414 exerted radiosensitizing effects.