AKT1 and central nervous system cancer: The other interrelations between HIF-1α, autophagy and radioprotection were revealed in colon cancer cells in which hypoxia-induced autophagy reduced their radiosensitivity via the HIF-1α/miR-210/Bcl-2 pathway [54] and, also, in hypoxic hepatoma and U251MG glioma cells, whose radiosensitivity was enhanced after reducing autophagy through the HIF-1/Akt/mTOR/P70S6K pathway [29].