The major players in intratumoral hypoxia-associated energy metabolism reprogramming are hexokinase 2 (HK2), glucose transporter 1 (GLUT1) and pyruvate dehydrogenase kinase 1 (PDK1); their HIF-1-mediated expression ensures the Warburg effect and thereby contributes to the radioresistance of hypoxic tumors by enhancing the antioxidant capacity of the involved cancer cells [110,111,119]. Here, PDK1 is linked to cancer.