In an in vitro model with human cervical carcinoma, the HDAC inhibitor trichostatin A was shown to be a potent radiosensitizer for HeLa cells under hypoxic conditions; the radiosensitizing effect of trichostatin A was correlated with the downregulation of the expression of HIF-1a and VEGF in hypoxic cancer cells [68]. This evidence concerns the gene VEGFA and cancer.