MTOR and hepatocellular carcinoma: As a result of hypoxia-induced energy metabolism reprogramming, the augmented PDK1 expression in hypoxic tumors can drive the PI3K/Akt/mTOR signaling that promotes the EMT and formation of the radioresistant CSC-like phenotype, as it was shown for PDK1-overexpressing hepatocellular carcinoma [120].