In turn, long intergenic noncoding (linc) RNA-p21 promotes the intracellular accumulation of HIF-1α by reducing its ubiquitination; this linc RNA-mediated stabilization/accumulation of HIF-1α confers the radioresistance of hypoxic hepatoma and glioma cells through the induction of autophagy and the antiapoptotic Akt/mTOR/P70S6K pathway [29]. This evidence concerns the gene RPS6KB1 and central nervous system cancer.