In human hepatoma cells, AMPK-activated histone deacetylase 5 (HDAC5) deacetylated HSP70, which, in turn, mediated the HSP90-HIF-1α interactions, followed by the nuclear translocation of HIF-1α and induction of the HIF-1-dependent transcription response [19]. Here, HIF1A is linked to hepatocellular carcinoma.