HIF1A and lung carcinoma: At the level of epigenetic regulation, the HIF-1-induced expression of microRNA-210 (miR-210) was shown to promote the enhanced radioresistance in hypoxic cells of lung cancer cell lines A549 and H1975; this was manifested in the decreased apoptotic death, improved growth and accelerated repair of the DNA double-stranded breaks in the irradiated cancer cells exhibiting the “miR-210 phenotype” [58].