This is exactly what was achieved by Iijima et al. [101], who used oxygen nanobubbles to radiosensitize lung cancer EBC-1 cells and breast cancer MDA-MB-231 cells: the intracellular levels of HIF-1α were reduced through its degradation resulting from oxygenation, while the oxygen effect-associated radioresistance was overcome. The gene discussed is HIF1A; the disease is breast carcinoma.