AKT1 and central nervous system cancer: As for hypoxia-responsive lncRNAs, the long, intergenic, noncoding RNA (lincRNA)-p21 expression was demonstrated to become elevated in SMMC7721 hepatoma and U251MG glioma cells in response to hypoxia or X-ray irradiation; the knockdown of lincPNA-p21 caused G2/M phase arrest, stimulated apoptosis and impaired autophagy via the HIF-1/Akt/mTOR/P70S6K pathway in the hypoxic cancer cells of both lines, which became radiosensitized [29].