Being the main player in triggering HSP expression, HSF1 also regulates the HIF-1α expression and tumor-driving HIF-1-HuR pathway, some protein kinase-based signaling pathways, autophagy, the energy metabolism and the redox potential, as well as the expression of certain microRNAs and long noncoding RNAs [160,161,162,163]; such activities allow HSF1 to contribute to many traits of tumor cells, including their ability to adapt to hypoxia and survive radiation exposure. This evidence concerns the gene HSF1 and neoplasm.