HIF1A and hepatocellular carcinoma: Besides, there is the hypoxia-responsive mutual regulation of MiR-199a-5p and HIF-1α in hepatocellular carcinoma cells: under hypoxia, the miR-199a-5p expression is suppressed by upregulated HIF-1α, which leads to the stimulation of glycolysis and realization of the Warburg effect, whereas, under normoxia, MiR-199a-5p directly targets the 3’-untranslated region (UTR) of HIF-1α transcripts, thereby suppressing both the expression of HIF-1α downstream glycolysis-related genes, which reduces the glucose uptake and lactate production [27].