HIF1A and central nervous system cancer: Using a knockdown technique with small hairpin (sh) RNA, Heller et al. [122] showed that transketolase-like protein 1—a key enzyme of PPP in some tumors and a target of HIF-1α—preserves hypoxia-stressed LNT229 glioma cells from the increase in the intracellular ROS level and is necessary for their adaptation to oxygen deficiency and the acquisition of radioresistance.