It was elucidated in another study that the overexpression of AHIF (antisense transcript of HIF-1α) found in glioblastoma multiforme cells/tissue is the endogenous factor that defines the generation of radioresistance-spreading exosomes [326]; consequently, inhibiting AHIF overexpression in glioblastoma multiforme may increase the radiosensitivity of this type of tumor. The gene discussed is HIF1A; the disease is glioblastoma.