Taking into consideration that HSF1 and inducible HSPs are some of the major players in cancer cell responses to both hyperthermia [232,233] and hypoxia (see Section 4.1, Section 4.2, Section 4.3, Section 4.4, above), one can suggest that the inhibitory targeting of the HSF1 activation/HSP induction pathway and/or the functional activities of major HSPs (HSP90, HSP70 and HSP27) would improve the radiosensitizing effects of hyperthermia toward hypoxic tumors. This evidence concerns the gene HSPB1 and cancer.