HIF1A and neoplasm: Among the beneficial effects achieved in the target tumor, there were the reduced expression of HIF-1α and VEGF, lower microvessel density, endogenous generation of O2 from H2O2 (i.e., artificial oxygenation overcoming the oxygen effect), enhanced production of ROS, cell cycle arrest, additional DNA double-stranded breaks and increased apoptosis after X-ray irradiation—all this allowed the authors to talk about the synergistic enhancement of the radiation response in hypoxic cancer cells [91].