SIRT1 and early-onset autosomal dominant Alzheimer disease: Of note, neuronal SIRT1 has the potential to slow down Alzheimer’s disease during CR [416], and fasting enhances the SIRT1 mediated deacetylation of PPARγ, which activates PGC1α and regulates the rate-limiting enzyme for amyloid beta (Aβ) generation [417].