M. bovis can induce the expression of important cytokine (TNF-α, IL-1 β, IL-18, IL-2, IL-12, IFN-γ, and IL- 6) genes in bovine PBMCs at a multiplicity of infection (MOI) of 1000, as recorded by Gondaira et al. [30]. The gene discussed is IFNG; the disease is infection.