IL1B and peeling skin syndrome: In fact, all of these pieces of evidence documented the central role of the inflammation in the ocular surface involvement in patients with pSS, as the increased level of pro-inflammatory cytokines has been discovered on the ocular surface and in tears; in particular, TNF-α, IL-1α, IL-1β, 1β, IL-6, and IFN-γ were commonly found in these subjects [104,105].