Six out of seven genes (ANXA3, CLEC4D, LMNB1, PRRG4, TNFAIP6 and VNN1) were overexpressed in the blood of CRC patients, and one (IL2RB) was under expressed with a blinded validation test set resulting in 72% sensitivity and 70% specificity, with similar predictive values for left- and right-sided CRC. This evidence concerns the gene PRRG4 and colorectal carcinoma.