Seventeen proteins showed significantly different concentrations between CRC and controls, nine were overexpressed (CEA, GDF-15, AREG, IL-6, CXCL10, CXCL9, PSA, TNFα, cathepsin-D), and eight were downregulated (HGF receptor, CXCL5, ERBB4, FLT3L, CD69, EMMPRIN, VEGFR-2, Caspase-3). The gene discussed is TNF; the disease is colorectal carcinoma.