MKI67 and neoplasm: Despite high expression of the proliferation marker MKI67, previously reported to preferentially mark TA-like cells [42], regions of CA9 expression were largely overlapping with MKI67− areas in most patient tumors, suggesting that tumor cells with expression of the hypoxia/glycolysis signature were indeed less proliferative, and actively cycling TA-like cells might prefer OXPHOS to generate energy (Figure S5c).