Adipose-specific SREBP-1c transgenic mice display spontaneous hepatic steatosis, hyperglycemia, hypertriglyceridemia, insulin resistance and diabetes at the age of 8 weeks [84] and at 20 weeks of age, their livers show typical NASH features, pericellular fibrosis, ballooning degeneration, and Mallory Denk bodies [84]. The gene discussed is SREBF1; the disease is metabolic dysfunction-associated steatohepatitis.