Recent studies showed that intracellular Chol transport is also altered in NAFLD and NASH, including increased expression of a main caveolae scaffold protein caveolin-1 involved in Chol-binding and transport, steroidogenic acute regulator (StAR)-related lipid transfer proteins involved in Chol transport from intracellular stores to the mitochondria, and oxysterol-binding protein (OSBP), decreased expression of Niemann–Pick C1 (NPC1) involved in the egress of Chol from the endosomal/lysosomal compartment [63,121]. This evidence concerns the gene OSBP and metabolic dysfunction-associated steatohepatitis.