Other potential approaches to reduce liver Chol or to decrease Chol-mediated liver injury for the treatment of NASH and HCC include thyroid hormone receptor agonists [151], activation of the glucagon-like peptide-1 receptor (GLP-1R) [152], and genetic deletion or silencing of miR-122 [153]. Here, GLP1R is linked to metabolic dysfunction-associated steatohepatitis.