We found that the majority of ICC markers were highly and equally expressed in both GIST subgroups; however, we found THBS4 and ELOVL6 that were more expressed, as well as EDN3 and GJA1 that were underexpressed in SDH-deficient GISTs (Supplementary Figure S1). The gene discussed is EDN3; the disease is intrahepatic cholangiocarcinoma.