FGF1 and cancer: These molecules have been widely reported as modulators of the tumorigenic process by controlling signaling loops leading to unregulated cell growth, cancer progression, angiogenesis, and metastasis [32].Particularly interesting is the fact that specific groups of GAGs, such as the heparan sulfates, are able to trigger cell proliferation mechanisms through fibroblast growth factors (FGF1 and FGF2), vascular endothelial growth factor (VEGF), and transforming growth factor-β signaling [32,33].