Although we have not confirmed the significant relation between the severity of AD and the level of specific IgE (classes 0–4) to Mala s 6, Asp f 6 and to allergen extract Sacc according to the level of specific IgE (classes 0, 1, 2, 3, 4), this difference being nearly significant (p-value = 0.064091 for Mala s 6, p-value =0.05590 for Sacc and p-value = 0.05773 for Asp f 6), Table 4. Here, IGHE is linked to Alzheimer disease.