In addition, the prominent caspase-8 activation induced by Palm on 1.1E7 cells, an effect previously unpublished for human β-cells, might be connected with the caspase-8 recently described role as a serum early marker for T2DM in humans, though since this is data from cell lines, it must be interpreted with caution. Here, CASP8 is linked to type 2 diabetes mellitus.