A microarray study showed that genes coding for Wnt ligands and for Frizzled receptors exhibited either significantly increased (WNT2B, WNT3A, WNT5B, WNT6, WNT7A, WNT9A, WNT11, FZD3 and FZD4) or decreased (FZD1 and FZD5) gene expression in ulcerative colitis compared to non-IBD patients [75]. This evidence concerns the gene FZD3 and ulcerative colitis.