TLR4 and inflammatory bowel disease: For example, Yang et al. [47] showed that EGCG ((−)-epigallocatechin-3-gallate), a green tea polyphenol, downregulates TLR-4 expression and blocks NF-kB activity in LPS-stimulated intestinal cell line IEC-6 and suggests that it may be effective as an anti-inflammatory factor in IBD.