In addition to its classical role in promoting the desensitization and internalization of GPCRs, GRK2 may regulate non-GPCRs (e.g., through a direct association of GRK2 with the G beta-gamma complex [Gβγ], leading to desensitization of certain ion channels, or through GRK2-induced desensitization of the sphingosine-1-phosphate receptor [S1PR] that regulates lymphocyte migration into sites of infection). This evidence concerns the gene GRK2 and infection.