RARRES2 and neoplasm: Recently it was demonstrated that a topical application of ATRA could inhibit melanoma growth, not only by exerting a differentiating effect, but also by influencing tumor immunity by up-regulation of chemerin, which in turn enhances Chemochine Like Receptor-1 (CMKLR-1)-expressing natural killer cell infiltration, creating an immunosuppressive tumor environment [3,4].