Examples of gatekeeper mutations are T790M in EGFR-mutant NSCLC, L1196M in ALK-rearranged NSCLC and L2026M in ROS-1 positive NSCLC, while typical solvent front mutations are G1202R in ALK-rearranged NSCLC and G2032R in ROS-1 positive NSCLC [90,91,92,93]. This evidence concerns the gene ROS1 and non-small cell lung carcinoma.