In a glioblastoma (GBM) model, the expression of MHC-I and -II, APM molecules and ligands of NKG2D (MHC class I–related chains A and B (MICA/B), UL16 binding proteins (ULBPs)) have been reported down-regulated or defective in CSCs [31]. The gene discussed is KLRK1; the disease is glioblastoma.