Since the pattern of neuroimmune activation in AUD is shared in other degenerative diseases, TRAIL may represent an important mediator of neuronal death in other conditions involving TLR7 activation such as viral infection [10,11,12] or Alzheimer’s disease (AD) [10,11,12,17,55,56], and it may represent a promising therapeutic target. The gene discussed is TNFSF10; the disease is viral infectious disease.