In AD and healthy human post-mortem brains, transcriptional analyses of isolated astrocytes from different regions revealed differential expression of genes in pathways regulating cytoskeleton (MYO6, KIF21A, ACTNB), cell signalling (IGF1R, PIK3R1, MAP3K12), tight junctions (GJC1, ZO1, TJAP1) [136], and lipid metabolism (ACOT1, ACOT2) [137], as well as dysregulation of mitochondria-related genes (TRMT61B, FASTKD2, NDUFA4L2) and immune response genes (CLU, C3, CD74) [112] (Table 1). This evidence concerns the gene CLU and Alzheimer disease.