The transcription factor TFEB, a master regulator of lysosomal function, is upregulated in AD astrocytes; TFEB was found to drive a network of ten AD GWAS genes (BIN1, CLDN11, POLN, STK32B, EDIL3, AKAP12, HECW1, WDR5, LEMD2, and DLC1). This evidence concerns the gene POLN and Alzheimer disease.