In AD and healthy human post-mortem brains, transcriptional analyses of isolated astrocytes from different regions revealed differential expression of genes in pathways regulating cytoskeleton (MYO6, KIF21A, ACTNB), cell signalling (IGF1R, PIK3R1, MAP3K12), tight junctions (GJC1, ZO1, TJAP1) [136], and lipid metabolism (ACOT1, ACOT2) [137], as well as dysregulation of mitochondria-related genes (TRMT61B, FASTKD2, NDUFA4L2) and immune response genes (CLU, C3, CD74) [112] (Table 1). The gene discussed is C3; the disease is Alzheimer disease.