The inhibition of NF-κB kinase subunit alpha (IKKα) activity blocks the interleukin 6 (IL-6)/STAT-3 signalling pathway leading to a decrease in proliferation, migration, and invasion by inducing apoptosis of prostate cancer cells and inhibits tumour formation in a xenograft mouse model [40]. The gene discussed is IL6; the disease is Familial prostate cancer.