HERC5 and COVID-19: Of the 134 Antiviral defense keywords, 27 were up-regulated by SARS-CoV-2 and are listed in Figure 2C. Many of these genes, including IFIT1, IFIT2, IFIT3, RSAD2, OASL, HERC5, DDX58 and MX2 were also upregulated in nasopharyngeal swabs of COVID19 patients [6].