Our recent observations have linked OTX015 antitumor activity to a marked downregulation of GNL3 gene [11], coding for the G nucleolar 3 protein (often indicated as nucleostemin) that is implied in growth, survival, genome stability and stemness capacities of various cancer cell types [24], this being also related with cancer resistance to conventional treatments [24,25,26,27,28]. Here, GNL3 is linked to cancer.