OCs and myeloma cells produce Wnt signaling inhibitors such as sclerostin (Scl), DKK-1, and the secreted, frizzled-related protein 2 (SFRP-2) to suppress OB activity, resulting in decreased osteoblastogenesis, which contributes to MM-related bone resorption and disease progression. The gene discussed is DKK1; the disease is Miyoshi myopathy.