Particularly, mutations and/or translocations in the BCL6 genomic locus are quite important in B-cell lymphomas, since BCL6 is a transcription repressor targeting many genes, including PRDM1, TP53, CDKN1A and BCL2, thus controlling the germinal B-cell formation, cell cycle, and differentiation [48,49]. The gene discussed is BCL6; the disease is B-cell non-Hodgkin lymphoma.