MT-ND4 and Leber hereditary optic neuropathy: Interestingly, the early observation on the m.11778G > A/MT-ND4 and m.3460G > A/MT-ND1 mutations documenting the change in rotenone sensitivity in LHON patients [29,32] is now substantiated by the identification of binding sites to this potent complex I inhibitor in both the ND4 and ND1 subunits [37].