Briefly discussing the role of GRKs in cancer, GRK1 and GRK7 were shown to play a role in embryogenesis, while interacting indirectly with Rho GDP-dissociation inhibitor (RhoGDI) and phosphodiesterase γ (PDEγ), both of which are shown to be abnormally regulated in cancer [153,154]. Here, GRK1 is linked to cancer.