Although HNK degraded EGFR protein in HCC cells (Figure 5B and Figure S5B) without the increased of EGFR mRNA expression (Figure S6A,B), HNK suppressed Egfr and Fkbp5 mRNA expression upregulated in HFD-fed MUP-uPA livers (Figure 3A), whose mechanism(s) should be further investigated. The gene discussed is PLAU; the disease is hepatocellular carcinoma.