We found that honokiol (HNK) can prevent HCC development in a NAFLD mouse model induced by diethylnitrosamine (DEN) treatment and high-fat diet (HFD) feeding and in a major urinary protein (MUP)-urokinase type plasminogen activator (uPA) transgenic NASH mouse model [12,13]. The gene discussed is PLAU; the disease is hepatocellular carcinoma.