MSCs cultured in medium without AML-CM showed detectable release for 140 of the 146 proteins that had significantly increased abundance in MSC/AML-CM culture supernatants; thus, only a small minority of these proteins (CD82, ADAM17, SCP2, S100B, CPNE3 and LRMP) was not detected in the MSC supernatants. This evidence concerns the gene CPNE3 and acute myeloid leukemia.