MSCs cultured in medium without AML-CM showed detectable release for 140 of the 146 proteins that had significantly increased abundance in MSC/AML-CM culture supernatants; thus, only a small minority of these proteins (CD82, ADAM17, SCP2, S100B, CPNE3 and LRMP) was not detected in the MSC supernatants. The gene discussed is SCP2; the disease is acute myeloid leukemia.