Their membrane proteome contains several beta thalassemia signatures related to the expression of structural, lipid raft, chaperoning, proteasome, redox, transport, antigenic, and enzyme components, including the upregulation of myosin, arginase-1, glutathione transferase, and protein kinases, but downregulation of transporters involved in nitrogen, purine, and amino acid metabolism. The gene discussed is ARG1; the disease is Beta-thalassemia.