CDH1 and breast carcinoma: Preliminary studies indicated a potential role for angiopoietin-2 as a prognostic factor in cancers, for instance breast cancer [43], lung cancer [44], and HCC [45], not only by inducing angiogenesis but also by encouraging metastasis via the α5β1 integrin/integrin-linked kinase (ILK)/Akt, GSK-3β/Snail/E-cadherin signaling pathway [46].