The crude and adjusted OR shown in Table 4, indicate that S100A9 (24.11, 22.5, p < 0.0001), MUC5AC (3.81, 3.78, p < 0.05), angiopoietin-2 (3.77, 5.17, p < 0.05), and CA19-9 (102.82, 129.44, p < 0.0001) could predict CCA from normal subjects in accordance with OR values. Here, ANGPT2 is linked to cholangiocarcinoma.