As shown in Table 2, high angiopoietin-2 and TGF-β1 levels were significantly correlated with late TNM stages (stage III-IV) (OR = 4.846, 5.333; p < 0.05) and only a high TGF-β1 level was associated with metastasis (OR = 3.467; p = 0.024) and lymph node metastasis (OR = 3.111). This evidence concerns the gene TGFB1 and metastatic malignant neoplasm in the lymph nodes.