NFE2L2 and cancer: In another work, the group of Mi-Kyoung investigated the role of NRF2 in the modulation of the cancer stem cell (CSC) phenotype, establishing a breast CSC-like model by isolating the subpopulations of MCF-7 (doxorubicin sensitive), MCF-7/ADR (doxorubicin-resistant) and MDA-MB-231 cells with high expression levels from cluster of differentiation 44 (CD44 high), a common CSC marker associated with drug resistance, tumor recurrence and metastasis formation [39].