NFE2L2 and breast cancer: Along similar lines of evidence, other research conducted on 4T1 and JC murine breast cancer cells has shown that the flavonoid fisetin, a known NRF2 activator, can exert a tumor-suppressive function by decreasing the expression of matrix metalloproteinases (MMP-2 and MMP-9), two key regulators of tumor invasion and metastatic spreading [35].