G6PD and breast cancer: More in detail, by using MCF-7 and MDA-MB-231 breast cancer cells, the authors showed that the inhibition of NRF2 and overexpression of Kelch-like ECH-associated protein-1 (KEAP1) reduced the expression of G6PD, while NRF2 overexpression or KEAP1 knockdown had the opposite effect.