Of note, these data were also confirmed in vivo, since the administration of the anticancer drug, PA-MSHA (Pseudomonas aeruginosa mannose-sensitive hemagglutinin) to MCF-7/ADR-xenografted mice was able to significantly impair the tumor growth by downregulating the NRF2 and p62 levels. The gene discussed is NFE2L2; the disease is neoplasm.