RHOA and breast carcinoma: In a quite recent study, the genetic silencing of NRF2 was found to significantly impair cell proliferation and migration in the MDA-MB-231 and MCF-7 breast cancer cells by downregulating the small GTPase and transforming protein RhoA, while its reconstituted expression was able to promote an increased growth rate and invasiveness, also restoring the levels of RhoA.