ESR1 and breast carcinoma: Breast cancer is a heterogeneous disease and is classified as a luminal A (estrogen receptor (ER) and/or progesterone receptor (PR) (+) and human epidermal growth factor receptor 2 (HER2) (−), with low ki-67 levels); luminal B (ER and/or PR (+) and HER2 (−), with high ki-67 levels); basal-like (also called triple-negative due to the lack of ER, PR and HER2 expression) and HER2-enriched (ER and PR (−) and HER (+)) molecular subtypes [2].