In this regard, Xu et al. demonstrated that the genetic silencing of NRF2 in MCF-7 breast cancer cells resistant to Adriamycin was paralleled by a marked upregulation of the CDCA4 protein (cell division cycle-associated protein 4) that was ultimately responsible of the enhanced growth and proliferation of these cells in vitro [32]. This evidence concerns the gene NFE2L2 and breast carcinoma.