The 6-SNP PRS-based model is composed of DIRC3_rs6759952, GAP43_rs13059137, NRG1_rs7834206, PROM1_rs72616195, LOC100507065_rs11175834, and LRP1B_rs1369535, that is, SNPs related to cell growth and inflammation were found to be positively associated with the risk of thyroid cancer. Here, LRP1B is linked to thyroid cancer.