Being a tumor suppressor, loss of BAP1 through germline and somatic mutations has been directly linked to the predisposition of BAP1-mutated individuals to various malignancies including mesothelioma [109,110,111,112,113,114], uveal melanoma [115,116], cutaneous melanoma [117], and clear cell renal cell carcinoma [118,119,120]. The gene discussed is BAP1; the disease is mesothelioma.