UBE2S is also reported to be a prognostic factor of hepatocellular carcinoma, and targeting UBE2S in high UBE2S-expressing cells restricts the proliferation and migration of tumor cells where increased expression of p53, p21, and cyclin D1 is seen after UBE2S suppression [37]. The gene discussed is CDKN1A; the disease is hepatocellular carcinoma.