DUBs can be categorized into five subclasses: Ubiquitin-specific proteases (USPs), ovarian tumor proteases (OTUs), Machado–Joseph domain proteases (MJDs), ubiquitin C-terminal hydrolases (UCHs), and Jab1/Mov34/Mpr1 Pad1 N-terminal+ (MPN+) (JAMM) domain metalloproteases [72]. Here, COPS5 is linked to ovarian neoplasm.