TGFBR3 and neoplasm: As summarized (Table 1), high levels of alpha-fetoprotein (AFP) (>20ng/mL)(p = 0.014), and advanced tumor stage in all grading systems, including UICC (p = 0.01), Edmonson (p = 0.003) and AJCC (p = 0.048), were found to be associated with low expression of TGFβR3.