As summarized (Table 1), high levels of alpha-fetoprotein (AFP) (>20ng/mL)(p = 0.014), and advanced tumor stage in all grading systems, including UICC (p = 0.01), Edmonson (p = 0.003) and AJCC (p = 0.048), were found to be associated with low expression of TGFβR3. The gene discussed is AFP; the disease is neoplasm.