SOD1 and Sepsis: Therefore, the increase in SOD activity and the parallel reduction in HMGB1 levels have been proposed as the mechanisms underlying the protective effects exerted by quercetin in a rat model of sepsis [238], the amelioration of the cisplatin-induced hepatotoxicity by the Ganoderma lucidum mushroom [239], and the anti-inflammatory effect of the midazolam–sufentanil combination [240].