More recently, Liang et al. demonstrated that in K-Ras-driven pancreatic ductal adenocarcinoma (PDAC), Nrf2 expression can be regulated by protein interacting with never in mitosis A1 (PIN), which increases the promoter activity of Nrf2 upregulating its transcription [64]. This evidence concerns the gene NFE2L2 and pancreatic ductal adenocarcinoma.