The increase of antioxidant response by Nrf2 is also involved in chemoresistance of colon cancer cells, where the inhibition of either Nrf2 or Her2, alone and in combination, caused a significant increase in oxaliplatin-induced cytotoxicity and apoptosis with a maximum effect in SW480/Res cells having low Her2 and Nrf2 expression levels [39]. The gene discussed is ERBB2; the disease is colonic neoplasm.