BACH1 and lung cancer: Bach1 may also activate transcription of several genes, including MMP1 and CXCR4, which are involved in inducing breast cancer metastasis [85], and promotes lung cancer metastasis by activating hexokinase 2 and glyceraldehyde 3-phosphate dehydrogenase transcription, and by increasing glucose uptake, glycolysis rates, and lactate secretion [86].