Although oxidative stress can be one of the major causes underlying hepatocellular carcinoma (HCC) development by driving DNA damage production and altered protein expression, in HCC patients, the increased expression of Nrf2, the master regulator of antioxidant genes, accompanied the increase of 8-hydroxyguanosine (8-OHdG) lesions, which was found to be associated with poor survival [35]. Here, NFE2L2 is linked to hepatocellular carcinoma.