Sphk1 is responsible for phosphorylation of sphingosine and production of S1P, and it was shown that Sphk1/S1P signaling can induce colorectal carcinogenesis through activation of the interleukin-6/signal transducer and activator of transcription (STAT)-3/protein kinase B pathway [78]. Here, SPHK1 is linked to medical procedure.