Hlavata et al. [133] showed that there were no differences in ABCG5 and ABCG8 mRNA levels between tumor and control tissues, with transcript levels decreasing from the colon to the rectum, while the other study provided evidence of reduced survival time in lymph-node-negative CRC patients with ABCG5-positive tumor buds [145]. Here, ABCG5 is linked to neoplasm.