Indeed, it was recently shown that serum HDL-C levels correlate with the specific immune signature of cancerous tissue in CRC patients, in particular with CD3 and CD8 markers, implying that high HDL-C and apoAI levels might be associated with enhanced recruitment and activity of CD3+ and CD8+ T cells, which exhibit antitumor activities [29]. This evidence concerns the gene CD8A and colorectal carcinoma.