The proliferation, invasiveness, and migration of human ABCA1-transfected colon adenocarcinoma cells can be inhibited by downregulation of cyclooxygenase 2 (COX-2), caused either by simultaneous transgenic overexpression of apoAI or by exogenous treatment with human recombinant apoAI [65]. Here, APOA1 is linked to colon adenocarcinoma.