TNF and obesity due to melanocortin 4 receptor deficiency: Recently, it has been reported that BPF phytocomplex exerts an anti-inflammatory activity in a diet-induced animal model of NAFLD, which reproducibly develops obesity, systemic inflammation, with crown-like bodies in adipose tissue, hypoadiponectinemia, increased IL-6 and TNFα, insulin resistance, dyslipidemia, progressing to NASH and fibrosis over time [138].