MAPK8 and obesity due to melanocortin 4 receptor deficiency: Furthermore, JNK1 and 2 mediate the recruitment and activation of macrofages in vWAT; in fact, HFD-fed mice with a macrophage-specific ablation of JNK exhibited a less severe insulin resistance and were largely protected from the inflammation associated with diet-induced obesity, through a decreased accumulation of ATM and a reduced expression of genes associated with M1 polarization [42,43] (Figure 3).