The GC-GR transcriptional dependence is clearly demonstrated in mice lacking hepatic GR that show an exaggerated hypoglycaemia after fasting as neither PEPCK, pyruvate carboxylase, nor G6Pase can be upregulated [57], although all three genes are involved in gluconeogenesis, G6Pase is, however, also involved in hepatic glucose release from glycogenolysis [58]. The gene discussed is NR3C1; the disease is Hypoglycemia.