Indeed, AML-derived EVs induce the downregulation of hematopoietic stem cell-supporting factors such as KIT ligand (KITL), C-X-C motif chemokine ligand (CXCL)12, and insulin growth factor (IGF)-1 in bone marrow stromal cells and reduce their ability to support normal hemopoiesis. Here, KITLG is linked to acute myeloid leukemia.