Ghosh et al. [27] found that circulating CLL-EVs can activate the AKT signaling pathway in CLL-bone marrow stromal cells with the production of vascular endothelial growth factor (VEGF), a survival factor for CLL B cells, highlighting the important role of EVs in the activation of the tumor microenvironment. Here, AKT1 is linked to B-cell chronic lymphocytic leukemia.