In support of this finding, a recent study by Luke’s group [23] highlights a differential cell-cycle regulation for the activity and the level of the RNASEH2A orthologous gene in yeast Saccharomyces cerevisiae (RNH201), peaking at S and G2 phases of the cell cycle, supporting the hypothesis that RNASEH2A plays a role in cancer progression. The gene discussed is RNASEH2A; the disease is cancer.