Recent data show that CDK5 phosphorylates the Gα–interacting vesicle-associated protein (GIV), a protein upregulated in numerous metastatic cancers, which promotes GIV interaction with Gαi, thereby promoting protein kinase B (PKB, Akt) phosphorylation, enzyme important in regulation of metabolism, cell survival, motility, transcription, and cell-cycle progression, actin remodeling, cell migration, and cell survival in podocytes (highly specialized cells of the kidney glomerulus) [230,231]. The gene discussed is AKT1; the disease is metastatic malignant neoplasm.