Furthermore, carcinogenic role of CDK12 was demonstrated through the expression and alternative last exon (ALE) splicing of genes with long transcripts and large numbers of exons, such as DNAJB6 (DnaJ Heat Shock Protein Family (Hsp40) Member B6), promoted cell invasion and migration in HER2-amplified breast cancer cells [146]. This evidence concerns the gene ERBB2 and breast cancer.