In parallel, RSV can act as a preventive chemo-agent and caloric restriction mimetic in humans by reducing IGF-1 (insulin-like growth factor-1) and IGFBP-3 (insulin-like growth factor-binding protein 3) as seen in 40 healthy volunteers who consumed RSV at doses of 0.5, 1.0, 2.5, or 5.0 g per day for 29 days, leading to a reduced risk of cancer [182]. The gene discussed is IGFBP3; the disease is cancer.