APP and cerebral amyloid angiopathy: The Dutch-type hereditary Cerebral Amyloid Angiopathy (D-CAA) also known as hereditary cerebral haemorrhage with amyloidosis Dutch type (HCHWA-D) is a rare autosomal dominant disorder and occurs due to the presence of a guanine to cytosine transversion point mutation on codon 693 of the amyloid precursor protein gene (APP E693Q) [8].