DLG4 and Alzheimer disease: In the frontal cortex of 3×Tg-AD mice, sulforaphane increased levels of neuronal and synaptic biomarkers, including: microtubule-associated protein 2 (MAP2), a dendritic marker and structural protein present in neurons; synaptophysin, a pre-synaptic protein; and postsynaptic density protein-95 (PSD-95), a membrane-associated protein located in neural postsynaptic densities [33].