NFE2L2 and Cognitive impairment: In another study, depletion of Nrf2 increases BACE1 and a BACE1 mRNA-stabilizing antisense RNA (BACE1-AS) expression and Aβ production and worsens cognitive deficits, and suggesting that sulforaphane-mediated Nrf2 activation decreases BACE1 and BACE1-AS expression and Aβ production and ameliorates cognitive deficits in 5×FAD and 3×Tg-AD mice [31].