ANG and Ureteral obstruction: This idea is also supported through work undertaken by Zimmerman et al., who found that Ang-(1-7) further increased the apoptosis and macrophage influx in obstructed kidneys from MasR-deficient mice, indicating that part of the detrimental effect of the heptapeptide is MasR-independent and might relate to a receptor that is especially upregulated in this experimental scenario of unilateral ureteral obstruction [122].