Additional explanations for such discrepancies in the WIR model might be technical (i.e., differences in species and strains and in the perturbations and AKI techniques applied), or advanced disruption of the ACE2/Ang-(1-7)/MasR pathway, which should be especially damaged in WIR, with extensive necrosis of the S3 segments of the proximal tubules [1,2]. Here, ACE2 is linked to acute kidney injury.