In another WIR-AKI study in non-diabetic ACE2 KO mice [112], the extent of neutrophil, macrophage, and T cell infiltration within the kidney increased, as compared with wild-type (WT) mice, along with the enhanced mRNA expression of pro-inflammatory cytokines (IL-1β, IL-6 and TNF) and chemokines (macrophage inflammatory protein-2 and monocyte chemoattractant protein-1). This evidence concerns the gene IL6 and acute kidney injury.