The importance of ACE2 in delaying the progression of CKD (via an AT1R-mediated mechanism) has been suggested in subtotal nephrectomized rats submitted to ACE2 inhibition [71], as well as in ACE2 KO Akita diabetic mice that exhibited a substantial acceleration of diabetic glomerulopathy and albuminuria [81]. The gene discussed is ACE2; the disease is chronic kidney disease.