The implemented homology modelling pipeline was based on the structural homology of the MFS superfamily members and two distinctive experimentally resolved structures: the human glucose transporter GLUT1, which facilitates the translocation of glucose across the membrane and has a prominent role in cancer metabolism, and a bacterial homolog of MCT4, the Syntrophobacter fumaroxidans MPOB. The gene discussed is SLC2A1; the disease is cancer.